Project ChARLI

WHAT IS THE CHARLI PROJECT ?

Children's Antibiotic Resistant infections in Low-Income countries: an international cohort study (ChARLI)


Currently, antibiotic resistanceAntibiotic resistance
Infections caused by antibiotic-resistant bacteria are increasing steadily worldwide in hospitals as well as in the community. These infections often have more severe outcomes than those caused by so called "sensitive" bacteria. As a consequence, they also require more expensive second-line treatments as well as a more careful and costly follow-up care for patients.
surveillance networks and epidemiologic research
focus mainly on industrialized countries. However, developing these activities in low-income countriesLow-income countries
The World Bank is a vital source of financial and technical assistance to developing countriesDeveloping country
This term is generally used to describe a nation with a low level of material well-being. Since no single definition of the term developing country is recognized internationally, the levels of development may vary widely within so-called developing countries. Some developing countries have high average standards of living.

The World Bank classifies all low- and middle-income countries as developing but notes, "The use of the term is convenient; it is not intended to imply that all economies in the group are experiencing similar development or that other economies have reached a preferred or final stage of development. Classification by income does not necessarily reflect development status".
around the world. It is not a bank in the common sense. It is made up of two unique development institutions owned by 187 member countries: the International Bank for Reconstruction and Development (IBRD) and the International Development Association (IDA). Each institution plays a different but collaborative role in advancing the vision of inclusive and sustainable globalization. The IBRD aims to reduce poverty in middle-income and creditworthy poorer countries, while the IDA focuses on the world's poorest countries.

For operational and analytical purposes, the World Bank's main criterion for classifying economies is gross national income (GNI) per capita. Based on its annual GNI per capita, every economy is classified as low-income, middle income (lower and upper middle income) or high income.
, which represent one of the principal environments for development and dissemination, is essential to contain the worrying spread of resistance.

The main objective of the ChARLI project is to assess the incidence as well as the medical and economic consequences of severe childhood and neonatal infections caused by antibiotic resistant bacteria. The investigation will include both healthcare associated, as well as community acquired infections.


In order to realize this project, an international paediatric cohort will be created and monitored within the Institut Pasteur International Network (IPIN). This internationally renowned network offers a large geographical and international presence, significant field expertise, as well as well-established partnerships at the local level.

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NEWS

April 5th, 2014
Fanny Chereau presented the results of her study on ESBL carriage among ChARLI mothers and during 16th international Congress on Infectious Diseases (ICID).
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March 1st, 2014
The ChARLI project is happy to announce the participation of two new international sites in Cambodia and Senegal.
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February 10th - 16th, 2014
Dr. Elisabeth Delarocque-Astagneau and Dr. Elsa Kermorvant , the referent paediatrician for the project, visited the Institut Pasteur in Madagascar and held training sessions with ChARLI pediatricians.
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April 14th - 25th, 2014
Michael Padget carried out a mission at the Institut Pasteur in Madagascar to ensure data quality and data tracking as well as to prepare the field for his PhD study on antibiotic consumption.
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August 21, 2014
Enrollment for the ChARLI project in Cambodia is now open. Five mothers have already been recruited
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